Human LAMP-1/CD107a Recombinant Protein (C-Fc) (HY332021)

Name: Human LAMP-1/CD107a Recombinant Protein (C-Fc)
Brand: abinScience
SKU: HY332021
Price: 298 USD
Availability: InStock

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1mg

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Número de catálogo	HY332021
Descripción	Recombinant Human CD107a/LAMP1 Protein, C-Fc (HY332021) expressed in Mammalian Cells, spanning Ala29-Met382. Purity: >90% by SDS-PAGE. Highlights ●Fc Fusion — Enhanced stability with Protein A/G purification compatibility. ●Mammalian Expression — Proper folding and native glycosylation. ●High Purity — >90% purity verified by SDS-PAGE.
Sistema de expresión	Mammalian cells
Número de acceso	P11279
Longitud de proteína	Ala29-Met382
Aplicaciones	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Especies	Homo sapiens (Human)
Naturaleza	Recombinant
Nivel de endotoxinas	Please contact with the lab for this information.
Pureza	>90% as determined by SDS-PAGE.
Peso molecular predicho	66.72 kDa
Forma	Lyophilized
Buffer de almacenamiento	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Reconstitución	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Envío	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativos	CD107 antigen-like family member A, CD107a, LAMP-1, LAMP1, Lysosome-associated membrane glycoprotein 1, Lysosome-associated membrane protein 1
Fondo	Lysosome-associated membrane glycoprotein 1 is a ~44 kDa protein. Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, lysosomal pH regulation, autophagy and cholesterol homeostasis. Acts as an important regulator of lysosomal lumen pH regulation by acting as a direct inhibitor of the proton channel TMEM175, facilitating lysosomal acidification for optimal hydrolase activity. Also plays an important role in NK-cells cytotoxicity. Mechanistically, participates in cytotoxic granule movement to the cell surface and perforin trafficking to the lytic granule. In addition, protects NK-cells from degranulation-associated damage induced by their own cytotoxic granule content. 1. Zhang, J. et al. (2023) Molecular cell 83, 2524-2539.e7. PMID: 37390818 2. Peters, PJ. et al. (1991) The Journal of experimental medicine 173, 1099-109. PMID: 2022921 3. Krzewski, K. et al. (2013) Blood 121, 4672-83. PMID: 23632890 4. Cohnen, A. et al. (2013) Blood 122, 1411-8. PMID: 23847195 5. Sawada, R. et al. (1993) The Journal of biological chemistry 268, 12675-81. PMID: 7685349
Nota	For research use only