Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol.
Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Expédition
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stabilité et stockage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Interleukin-6 receptor subunit alpha is a ~51 kDa protein. Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation leads to the regulation of the immune response, acute-phase reactions and hematopoiesis. The interaction with membrane-bound IL6R and IL6ST stimulates 'classic signaling', the restricted expression of the IL6R limits classic IL6 signaling to only a few tissues such as the liver and some cells of the immune system.
1. Larsen, JV. et al. (2017) Molecular and cellular biology 37. PMID: 28265003
2. Kang, S. et al. (2019) Immunity 50, 1007-1023. PMID: 30995492
3. Spencer, S. et al. (2019) The Journal of experimental medicine 216, 1986-1998. PMID: 31235509
Note
For research use only
Images
Bioactivity
Immobilized HY583021 Human CD126/IL6R/IL-6RA Recombinant Protein (C-Fc) at 2 μg/mL(100 μL/well) can bind HY328011 Human IL6 Recombinant Protein (C-His-Avi), the EC 50 is 63.7 ng/mL.
Bioactivity
Immobilized HY583021 Human CD126/IL6R/IL-6RA Recombinant Protein (C-Fc) at 2 μg/mL(100 μL/well) can bind HY328021 Human IL6 Recombinant Protein (C-His), the EC 50 is 115 ng/mL.
Bioactivity
Immobilized HY328011 Human IL6 Recombinant Protein (C-His-Avi) at 2 μg/mL(100 μL/well) can bind HY583021 Human CD126/IL6R/IL-6RA Recombinant Protein (C-Fc), the EC 50 is 222 ng/mL.
Bioactivity
Immobilized HY328021 Human IL6 Recombinant Protein (C-His) at 2 μg/mL(100 μL/well) can bind HY583021 Human CD126/IL6R/IL-6RA Recombinant Protein (C-Fc), the EC 50 is 162 ng/mL.
Bioactivity
Immobilized HY328041 Human IL6 Recombinant Protein (N-HSAD3 & C-His) at 2 μg/mL(100 μL/well) can bind HY583021 Human CD126/IL6R/IL-6RA Recombinant Protein (C-Fc), the EC 50 is 133 ng/mL.
Bioactivity
Immobilized HY328051 Human IL6 Recombinant Protein (C-Strep) at 2 μg/mL(100 μL/well) can bind HY583021 Human CD126/IL6R/IL-6RA Recombinant Protein (C-Fc), the EC 50 is 267 ng/mL.
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