Human CD177 Recombinant Protein (C-Fc) (HV109021)

Name: Human CD177 Recombinant Protein (C-Fc)
Brand: abinScience
SKU: HV109021
Price: 298 USD
Availability: InStock

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概要

カタログ番号	HV109021
説明	Recombinant Human CD177 Protein, C-Fc (HV109021) expressed in Mammalian Cells, spanning Met1-Gly407. Purity: >90% by SDS-PAGE. Highlights ●Fc Fusion — Enhanced stability with Protein A/G purification compatibility. ●Mammalian Expression — Proper folding and native glycosylation. ●High Purity — >90% purity verified by SDS-PAGE.
発現システム	Mammalian cells
アクセッション番号	Q8N6Q3
タンパク質長	Met1-Gly407
アプリケーション	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
種	Homo sapiens (Human)
性質	Recombinant
エンドトキシンレベル	Please contact with the lab for this information.
純度	>90% as determined by SDS-PAGE.
予測分子量	69.78 kDa
形態	Lyophilized
保存バッファー	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。
再構成	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
発送	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
安定性と保存	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
別名	CD177, CD177 antigen, HNA-2a, Human neutrophil alloantigen 2a, NB1, NB1 GP, NB1 glycoprotein, PRV-1, PRV1, Polycythemia rubra vera protein 1
背景	CD177 antigen is a ~46 kDa protein. In association with beta-2 integrin heterodimer ITGAM/CD11b and ITGB2/CD18, mediates activation of TNF primed neutrophils including degranulation and superoxide production. In addition, by preventing beta-2 integrin internalization and attenuating chemokine signaling favors adhesion over migration. Heterophilic interaction with PECAM1 on endothelial cells plays a role in neutrophil transendothelial migration in vitro. However, appears to be dispensable for neutrophil recruitment caused by bacterial infection in vivo. Acts as a receptor for the mature form of protease PRTN3 allowing its display at the cell surface of neutrophils. 1. Jerke, U. et al. (2011) The Journal of biological chemistry 286, 7070-81. PMID: 21193407 2. Bai, M. et al. (2017) Blood 130, 2092-2100. PMID: 28807980 3. Sachs, UJ. et al. (2007) The Journal of biological chemistry 282, 23603-12. PMID: 17580308 4. Wang, L. et al. (2013) European journal of haematology 90, 436-7. PMID: 23461681 5. von Vietinghoff, S. et al. (2007) Blood 109, 4487-93. PMID: 17244676 6. von Vietinghoff, S. et al. (2008) Clinical and experimental immunology 152, 508-16. PMID: 18462208 7. Kuckleburg, CJ. et al. (2013) Arteriosclerosis, thrombosis, and vascular biology 33, 275-84. PMID: 23202369
注意事項	For research use only

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参考文献

データシート

Human CD177 Recombinant Protein (C-Fc).pdf

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Human CD177 Recombinant Protein (C-Fc) (HV109021)

概要

イメージ

参考文献

データシート

SDS

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お問い合わせ