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| カタログ番号 | HD887012 |
|---|---|
| 説明 |
Recombinant Human CERS6 Protein, N-His (HD887012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | Q6ZMG9 |
| タンパク質長 | Glu56-Asp177 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | CERS6, CerS6, Ceramide synthase 6, EC:2.3.1.-, EC:2.3.1.291, LAG1 longevity assurance homolog 6, LASS6, Sphingoid base N-palmitoyltransferase CERS6 |
| 背景 | Ceramide synthase 6 is a ~44 kDa protein. Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward palmitoyl-CoA (hexadecanoyl-CoA; C16:0-CoA). Can use other acyl donors, but with less efficiency. N-acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively. Ceramides generated by CERS6 play a role in inflammatory response. Acts as a regulator of metabolism and hepatic lipid accumulation. 1. Mesika, A. et al. (2007) The Journal of biological chemistry 282, 27366-27373. PMID: 17609214 2. Lahiri, S. et al. (2007) FEBS letters 581, 5289-94. PMID: 17977534 3. Russo, SB. et al. (2013) The Journal of biological chemistry 288, 13397-409. PMID: 23530041 4. Sassa, T. et al. (2016) The Journal of biological chemistry 291, 7477-87. PMID: 26887952 5. Jojima, K. et al. (2020) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 34, 3318-3335. PMID: 31916624 6. Pascoa, TC. et al. (2025) Nature structural & molecular biology 32, 431-440. PMID: 39528795 |
| 注意事項 | For research use only |
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