Human Complement Factor B Recombinant Protein (C-His) (HF634011)

Name: Human Complement Factor B Recombinant Protein (C-His)
Brand: abinScience
SKU: HF634011
Price: 298 USD
Availability: InStock

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50ug
100ug
1mg

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概要
イメージ
参考文献
データシート
SDS

概要

カタログ番号	HF634011
説明	Recombinant Human CFB Protein, C-His (HF634011) expressed in Mammalian Cells, spanning Met1-Leu764. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●Mammalian Expression — Proper folding and native glycosylation. ●High Purity — >90% purity verified by SDS-PAGE.
発現システム	Mammalian cells
アクセッション番号	P00751
タンパク質長	Met1-Leu764
アプリケーション	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
種	Homo sapiens (Human)
性質	Recombinant
エンドトキシンレベル	Please contact with the lab for this information.
純度	>90% as determined by SDS-PAGE.
予測分子量	86.50 kDa
形態	Lyophilized
保存バッファー	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。
再構成	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
発送	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
安定性と保存	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
別名	BF, BFD, Ba, Bb, C3/C5 convertase, CFB, Complement factor B, Complement factor B Ba, Complement factor B Bb, EC:3.4.21.47, GBG, Glycine-rich beta glycoprotein, PBF2, Properdin factor B
背景	Complement factor B is a ~85 kDa protein. Precursor of the catalytic component of the C3 and C5 convertase complexes of the alternative pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. The alternative complement pathway acts as an amplification loop that enhances other complement pathways (classical, lectin and GZMK) by promoting formation of additional C3 and C5 convertases. CFB is cleaved and activated by CFD to generate Ba and Bb chains; Bb chain constituting the catalytic component of the C3 and C5 convertases. 1. Pangburn, MK. et al. (1986) The Biochemical journal 235, 723-30. PMID: 3638964 2. Vogt, W. et al. (1978) Immunology 34, 29-40. PMID: 624565 3. DiScipio, RG. et al. (1983) The Journal of biological chemistry 258, 10629-36. PMID: 6554279 4. Vogel, CW. et al. (1982) The Journal of biological chemistry 257, 8292-9. PMID: 6919543 5. Hourcade, DE. et al. (1998) The Journal of biological chemistry 273, 25996-6000. PMID: 9748277 6. Niemann, MA. et al. (1980) Biochemistry 19, 1576-83. PMID: 6769474
注意事項	For research use only