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| カタログ番号 | HC778012 |
|---|---|
| 説明 |
Recombinant Human CHD1L Protein, N-His (HC778012) expressed in E. coli, spanning Ser716-Pro897. Purity: >90% by SDS-PAGE.
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | Q86WJ1 |
| タンパク質長 | Ser716-Pro897 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 予測分子量 | 22.48 kDa |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | ALC1, Amplified in liver cancer protein 1, CHD1L, Chromodomain-helicase-DNA-binding protein 1-like, EC:3.6.4.- |
| 背景 | ATP-dependent chromatin remodeler CHD1L is a ~101 kDa protein. ATP-dependent chromatin remodeler that mediates chromatin-remodeling following DNA damage. Recruited to DNA damage sites through interaction with poly-ADP-ribose: specifically recognizes and binds histones that are poly-ADP-ribosylated on serine residues in response to DNA damage. Poly-ADP-ribose-binding activates the ATP-dependent chromatin remodeler activity, thereby regulating chromatin during DNA repair. Catalyzes nucleosome sliding away from DNA breaks in an ATP-dependent manner. Chromatin remodeling activity promotes PARP2 removal from chromatin. 1. Ahel, D. et al. (2009) Science (New York, N.Y.) 325, 1240-3. PMID: 19661379 2. Lehmann, LC. et al. (2017) Molecular cell 68, 847-859.e7. PMID: 29220652 3. Singh, HR. et al. (2017) Molecular cell 68, 860-871.e7. PMID: 29220653 4. Lehmann, LC. et al. (2020) Cell reports 33, 108529. PMID: 33357431 5. Wang, L. et al. (2021) Nature communications 12, 4057. PMID: 34210977 6. Bacic, L. et al. (2021) eLife 10. PMID: 34486521 7. Mohapatra, J. et al. (2021) eLife 10. PMID: 34874266 |
| 注意事項 | For research use only |
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