Human CHRNA3 Recombinant Protein (N-His) (HB019022)

Name: Human CHRNA3 Recombinant Protein (N-His)
Brand: abinScience
SKU: HB019022
Price: 211 USD
Availability: InStock

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Numéro de catalogue	HB019022
Description	Recombinant Human CHRNA3 Protein, N-His (HB019022) expressed in E. coli, spanning Ser32-Leu240. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Système d'expression	E. coli
Numéro d'accès	P32297
Longueur de protéine	Ser32-Leu240
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Espèces	Homo sapiens (Human)
Nature	Recombinant
Niveau d'endotoxines	Please contact with the lab for this information.
Pureté	>90% as determined by SDS-PAGE.
Masse moléculaire prédite	26.91 kDa
Forme	Lyophilized
Tampon de stockage	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Expédition	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs	CHRNA3, NACHRA3, Neuronal acetylcholine receptor subunit alpha-3
Contexte	Neuronal acetylcholine receptor subunit alpha-3 is a ~57 kDa protein. Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators. CHRNA3 forms heteropentameric neuronal acetylcholine receptors with CHRNB2 and CHRNB4, with CHRNA5, and CHRNB3 as accesory subunits. CHRNA3:CHRNB4 being predominant in neurons of the autonomic ganglia, it is known as ganglionic nicotinic receptor. 1. Gharpure, A. et al. (2019) Neuron 104, 501-511.e6. PMID: 31488329 2. Mann, N. et al. (2019) American journal of human genetics 105, 1286-1293. PMID: 31708116 3. Kuryatov, A. et al. (2011) Molecular pharmacology 79, 119-25. PMID: 20881005 4. Wang, F. et al. (1996) The Journal of biological chemistry 271, 17656-65. PMID: 8663494
Note	For research use only

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Human CHRNA3 Recombinant Protein (N-His).pdf

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