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| カタログ番号 | HB019022 |
|---|---|
| 説明 |
Recombinant Human CHRNA3 Protein, N-His (HB019022) expressed in E. coli, spanning Ser32-Leu240. Purity: >90% by SDS-PAGE.
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | P32297 |
| タンパク質長 | Ser32-Leu240 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 予測分子量 | 26.91 kDa |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | CHRNA3, NACHRA3, Neuronal acetylcholine receptor subunit alpha-3 |
| 背景 | Neuronal acetylcholine receptor subunit alpha-3 is a ~57 kDa protein. Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators. CHRNA3 forms heteropentameric neuronal acetylcholine receptors with CHRNB2 and CHRNB4, with CHRNA5, and CHRNB3 as accesory subunits. CHRNA3:CHRNB4 being predominant in neurons of the autonomic ganglia, it is known as ganglionic nicotinic receptor. 1. Gharpure, A. et al. (2019) Neuron 104, 501-511.e6. PMID: 31488329 2. Mann, N. et al. (2019) American journal of human genetics 105, 1286-1293. PMID: 31708116 3. Kuryatov, A. et al. (2011) Molecular pharmacology 79, 119-25. PMID: 20881005 4. Wang, F. et al. (1996) The Journal of biological chemistry 271, 17656-65. PMID: 8663494 |
| 注意事項 | For research use only |
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