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| カタログ番号 | HC882012 |
|---|---|
| 説明 |
Recombinant Human CHUK Protein, N-His (HC882012) expressed in E. coli, spanning Met1-Ser390. Purity: >90% by SDS-PAGE.
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | O15111 |
| タンパク質長 | Met1-Ser390 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 予測分子量 | 46.40 kDa |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | CHUK, Conserved helix-loop-helix ubiquitous kinase, EC:2.7.11.10, I-kappa-B kinase 1, I-kappa-B kinase alpha, IKK-1, IKK-A, IKK-alpha, IKK1, IKKA, IkBKA, IkappaB kinase, Inhibitor of nuclear factor kappa-B kinase subunit alpha, NFKBIKA, Nuclear factor NF-kappa-B inhibitor kinase alpha, TCF-16, TCF16, Transcription factor 16 |
| 背景 | Inhibitor of nuclear factor kappa-B kinase subunit alpha is a ~84 kDa protein. Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as a part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Negatively regulates the pathway by phosphorylating the scaffold protein TAXBP1 and thus promoting the assembly of the A20/TNFAIP3 ubiquitin-editing complex (composed of A20/TNFAIP3, TAX1BP1, and the E3 ligases ITCH and RNF11). 1. Solt, LA. et al. (2008) Immunologic research 42, 3-18. PMID: 18626576 2. Régnier, CH. et al. (1997) Cell 90, 373-83. PMID: 9244310 3. DiDonato, JA. et al. (1997) Nature 388, 548-54. PMID: 9252186 4. Mercurio, F. et al. (1997) Science (New York, N.Y.) 278, 860-6. PMID: 9346484 5. Liu, Y. et al. (2022) International journal of biological macromolecules 219, 571-578. PMID: 35952808 |
| 注意事項 | For research use only |
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