Human Clcn1 Recombinant Protein (N-His) (HW489012)

Name: Human Clcn1 Recombinant Protein (N-His)
Brand: abinScience
SKU: HW489012
Price: 211 USD
Availability: InStock

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50ug
100ug
1mg

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Каталожный номер	HW489012
Описание	Recombinant Human Clcn1 Protein, N-His (HW489012) expressed in E. coli, spanning Leu587-Gly877. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Система экспрессии	E. coli
Номер доступа	P35523
Длина белка	Leu587-Gly877
Применения	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Виды	Homo sapiens (Human)
Характер	Recombinant
Уровень эндотоксинов	Please contact with the lab for this information.
Чистота	>90% as determined by SDS-PAGE.
Прогнозируемая молекулярная масса	34.51 kDa
Форма	Lyophilized
Буфер хранения	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Реконституция	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Доставка	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Альтернативные названия	CLC1, CLCN1, Chloride channel protein 1, Chloride channel protein, skeletal muscle, ClC-1
Фон	Chloride channel protein 1 is a ~108 kDa protein. Voltage-gated chloride channel involved in skeletal muscle excitability. Generates most of the plasma membrane chloride conductance in skeletal muscle fibers, stabilizes the resting membrane potential and contributes to the repolarization phase during action potential firing. Forms a homodimeric channel where each subunit has its own ion conduction pathway. Conducts double-barreled currents controlled by two types of gates, two fast glutamate gates that control each subunit independently and a slow common gate that opens and shuts off both subunits simultaneously. Has a significant open probability at muscle resting potential and is further activated upon membrane depolarization. 1. Ryan, A. et al. (2002) The Journal of physiology 545, 345-54. PMID: 12456816 2. Bennetts, B. et al. (2005) The Journal of biological chemistry 280, 32452-8. PMID: 16027167 3. Ulzi, G. et al. (2012) Journal of the neurological sciences 318, 65-71. PMID: 22521272 4. Weinberger, S. et al. (2012) The Journal of physiology 590, 3449-64. PMID: 22641783 5. Portaro, S. et al. (2015) Neuromolecular medicine 17, 285-96. PMID: 26007199 6. Ronstedt, K. et al. (2015) Scientific reports 5, 15382. PMID: 26502825 7. Vindas-Smith, R. et al. (2016) Human mutation 37, 74-83. PMID: 26510092 8. Lorenz, C. et al. (1994) Human molecular genetics 3, 941-6. PMID: 7951242 9. Steinmeyer, K. et al. (1994) The EMBO journal 13, 737-43. PMID: 8112288 10. Pusch, M. et al. (1994) Biophysical journal 66, 149-52. PMID: 8130334
Примечание	For research use only

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Даташит

Human Clcn1 Recombinant Protein (N-His).pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

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C₁ × V₁ = C₂ × V₂

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C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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