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| カタログ番号 | HD953012 |
|---|---|
| 説明 |
Recombinant Human CPT1C Protein, N-His (HD953012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | Q8TCG5 |
| タンパク質長 | Ser178-Gln790 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | CATL1, CPT I-C, CPT1C, CPTI-B, Carnitine O-palmitoyltransferase 1, brain isoform, Carnitine palmitoyltransferase 1C, Carnitine palmitoyltransferase I, EC:3.1.2.22, Palmitoyl thioesterase CPT1C |
| 背景 | Palmitoyl thioesterase CPT1C is a ~90 kDa protein. Palmitoyl thioesterase specifically expressed in the endoplasmic reticulum of neurons. Modulates the trafficking of the glutamate receptor, AMPAR, to plasma membrane through depalmitoylation of GRIA1. Also regulates AMPR trafficking through the regulation of SACM1L phosphatidylinositol-3-phosphatase activity by interaction in a malonyl-CoA dependent manner. Binds malonyl-CoA and couples malonyl-CoA to ceramide levels, necessary for proper spine maturation and contributing to systemic energy homeostasis and appetite control. Binds to palmitoyl-CoA, but does not have carnitine palmitoyltransferase 1 catalytic activity or at very low levels. 1. Gratacòs-Batlle, E. et al. (2018) Frontiers in molecular neuroscience 11, 275. PMID: 30135643 2. Wolfgang, MJ. et al. (2006) Proceedings of the National Academy of Sciences of the United States of America 103, 7282-7. PMID: 16651524 3. Rinaldi, C. et al. (2015) JAMA neurology 72, 561-70. PMID: 25751282 |
| 注意事項 | For research use only |
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