

| Número de catálogo | HD963012 |
|---|---|
| Descripción |
Recombinant Human CREB3L1 Protein, N-His (HD963012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| Sistema de expresión | E. coli |
| Número de acceso | Q96BA8 |
| Longitud de proteína | Glu264-Pro392 |
| Aplicaciones | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| Especies | Homo sapiens (Human) |
| Naturaleza | Recombinant |
| Nivel de endotoxinas | Please contact with the lab for this information. |
| Pureza | >90% as determined by SDS-PAGE. |
| Forma | Lyophilized |
| Buffer de almacenamiento | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote. |
| Reconstitución | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Envío | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Estabilidad y almacenamiento | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Nombres alternativos | CREB3L1, Cyclic AMP-responsive element-binding protein 3-like protein 1, OASIS, Old astrocyte specifically-induced substance, Processed cyclic AMP-responsive element-binding protein 3-like protein 1, cAMP-responsive element-binding protein 3-like protein 1 |
| Fondo | Cyclic AMP-responsive element-binding protein 3-like protein 1 is a ~57 kDa protein. Precursor of the transcription factor form (Processed cyclic AMP-responsive element-binding protein 3-like protein 1), which is embedded in the endoplasmic reticulum membrane with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress or DNA damage, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus where it activates transcription of specific target genes involved in the cell-cycle progression inhibition. 1. Omori, Y. et al. (2002) Biochemical and biophysical research communications 293, 470-7. PMID: 12054625 2. Murakami, T. et al. (2006) Journal of neurochemistry 96, 1090-100. PMID: 16417584 3. Chen, Q. et al. (2014) PloS one 9, e108528. PMID: 25310401 4. Denard, B. et al. (2011) Cell host & microbe 10, 65-74. PMID: 21767813 |
| Nota | For research use only |
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