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| カタログ番号 | HD732012 |
|---|---|
| 説明 |
Recombinant Human CREBBP Protein, N-His (HD732012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | Q92793 |
| タンパク質長 | Thr1331-Glu1576 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | CBP, CREB-binding protein, CREBBP, EC:2.3.1.-, EC:2.3.1.48, Histone lysine acetyltransferase CREBBP, Protein lactyltransferas CREBBP, Protein-lysine acetyltransferase CREBBP |
| 背景 | CREB-binding protein is a ~265 kDa protein. Acetylates histones, giving a specific tag for transcriptional activation. Mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. 1. Jin, Q. et al. (2011) The EMBO journal 30, 249-62. PMID: 21131905 2. Das, C. et al. (2014) Proceedings of the National Academy of Sciences of the United States of America 111, E1072-81. PMID: 24616510 3. Chen, H. et al. (1999) Cell 98, 675-86. PMID: 10490106 4. Hung, HL. et al. (2001) The Journal of biological chemistry 276, 10715-21. PMID: 11154691 5. Masumi, A. et al. (2003) The Journal of biological chemistry 278, 25401-7. PMID: 12738767 6. Iioka, T. et al. (2003) Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 18, 1419-29. PMID: 12929931 7. Chen, S. et al. (2013) Molecular cell 52, 303-13. PMID: 24207024 8. Song, C. et al. (2017) Genes & development 31, 1370-1381. PMID: 28790157 9. Iyer-Bierhoff, A. et al. (2018) Cell reports 25, 2946-2954.e5. PMID: 30540930 10. Zhou, N. et al. (2022) Cell metabolism 34, 1023-1041.e8. PMID: 35675826 |
| 注意事項 | For research use only |
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