Human CTC1 Recombinant Protein (N-His) (HD264012)

Name: Human CTC1 Recombinant Protein (N-His)
Brand: abinScience
SKU: HD264012
Price: 211 USD
Availability: InStock

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Número de catálogo	HD264012
Descripción	Recombinant Human CTC1 Protein, N-His (HD264012) expressed in E. coli, spanning Asp893-Cys1217. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Sistema de expresión	E. coli
Número de acceso	Q2NKJ3
Longitud de proteína	Asp893-Cys1217
Aplicaciones	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Especies	Homo sapiens (Human)
Naturaleza	Recombinant
Nivel de endotoxinas	Please contact with the lab for this information.
Pureza	>90% as determined by SDS-PAGE.
Peso molecular predicho	38.14 kDa
Forma	Lyophilized
Buffer de almacenamiento	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Reconstitución	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Envío	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativos	C17orf68, CST complex subunit CTC1, CTC1, Conserved telomere maintenance component 1, HBV DNAPTP1-transactivated protein B
Fondo	CST complex subunit CTC1 is a ~134 kDa protein. Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST complex inhibits telomerase and is involved in telomere length homeostasis; it is proposed to bind to newly telomerase-synthesized 3' overhangs and to terminate telomerase action implicating the association with the ACD:POT1 complex thus interfering with its telomerase stimulation activity. 1. Miyake, Y. et al. (2009) Molecular cell 36, 193-206. PMID: 19854130 2. Chen, LY. et al. (2012) Nature 488, 540-4. PMID: 22763445 3. Wang, F. et al. (2014) Cell cycle (Georgetown, Tex.) 13, 3488-98. PMID: 25483097 4. Surovtseva, YV. et al. (2009) Molecular cell 36, 207-18. PMID: 19854131 5. Stewart, JA. et al. (2012) The EMBO journal 31, 3537-49. PMID: 22863775
Nota	For research use only

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Datasheet

Human CTC1 Recombinant Protein (N-His).pdf

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