Human CTC1 Recombinant Protein (N-His) (HD264012)

Name: Human CTC1 Recombinant Protein (N-His)
Brand: abinScience
SKU: HD264012
Price: 211 USD
Availability: InStock

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Numéro de catalogue	HD264012
Description	Recombinant Human CTC1 Protein, N-His (HD264012) expressed in E. coli, spanning Asp893-Cys1217. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Système d'expression	E. coli
Numéro d'accès	Q2NKJ3
Longueur de protéine	Asp893-Cys1217
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Espèces	Homo sapiens (Human)
Nature	Recombinant
Niveau d'endotoxines	Please contact with the lab for this information.
Pureté	>90% as determined by SDS-PAGE.
Masse moléculaire prédite	38.14 kDa
Forme	Lyophilized
Tampon de stockage	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Expédition	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs	C17orf68, CST complex subunit CTC1, CTC1, Conserved telomere maintenance component 1, HBV DNAPTP1-transactivated protein B
Contexte	CST complex subunit CTC1 is a ~134 kDa protein. Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST complex inhibits telomerase and is involved in telomere length homeostasis; it is proposed to bind to newly telomerase-synthesized 3' overhangs and to terminate telomerase action implicating the association with the ACD:POT1 complex thus interfering with its telomerase stimulation activity. 1. Miyake, Y. et al. (2009) Molecular cell 36, 193-206. PMID: 19854130 2. Chen, LY. et al. (2012) Nature 488, 540-4. PMID: 22763445 3. Wang, F. et al. (2014) Cell cycle (Georgetown, Tex.) 13, 3488-98. PMID: 25483097 4. Surovtseva, YV. et al. (2009) Molecular cell 36, 207-18. PMID: 19854131 5. Stewart, JA. et al. (2012) The EMBO journal 31, 3537-49. PMID: 22863775
Note	For research use only

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Human CTC1 Recombinant Protein (N-His).pdf

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