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| カタログ番号 | HC173012 |
|---|---|
| 説明 |
Recombinant Human CTPS1 Protein, N-His (HC173012) expressed in E. coli, spanning Met1-Lys557. Purity: >90% by SDS-PAGE.
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | P17812 |
| タンパク質長 | Met1-Lys557 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 予測分子量 | 65.12 kDa |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | CTP synthase 1, CTP synthetase 1, CTPS, CTPS1, EC:6.3.4.2, UTP--ammonia ligase 1 |
| 背景 | CTP synthase 1 is a ~66 kDa protein. CTP synthase involved in the de novo synthesis of CTP, a precursor of DNA, RNA and phospholipids. Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as a source of nitrogen. CTPS1 CTP synthase activity plays a crucial role in the proliferation of activated lymphocytes and immunity; additional CTP being required to meet increased demand for DNA, RNA and lipid membrane biosynthesis in proliferating lymphocytes. In addition to CTP synthase activity, also acts as a protein deamidase that catalyzes the side chain deamidation of specific asparagine residues of proteins to aspartate. Acts as a negative regulator of innate immunity by mediating deamidation of 'Asn-85' of IRF3, preventing IRF3 from binding DNA. 1. Han, GS. et al. (2005) The Journal of biological chemistry 280, 38328-36. PMID: 16179339 2. Choi, MG. et al. (2007) The Journal of biological chemistry 282, 5367-77. PMID: 17189248 3. Chang, YF. et al. (2007) The Journal of biological chemistry 282, 17613-22. PMID: 17463002 4. Martin, E. et al. (2014) Nature 510, 288-92. PMID: 24870241 5. Lynch, EM. et al. (2017) Nature structural & molecular biology 24, 507-514. PMID: 28459447 6. Lynch, EM. et al. (2021) Proceedings of the National Academy of Sciences of the United States of America 118. PMID: 34583994 8. Tian, Y. et al. (2025) Nature 641, 779-787. PMID: 40240600 |
| 注意事項 | For research use only |
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