Human CXCL10/IP-10 Recombinant Protein (N-GST & C-His) (HY524032)

Name: Human CXCL10/IP-10 Recombinant Protein (N-GST & C-His)
Brand: abinScience
SKU: HY524032
Price: 211 USD
Availability: InStock

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50ug
100ug
1mg

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Каталожный номер	HY524032
Описание	Recombinant Human CXCL10/IP-10 Protein, N-GST & C-His (HY524032) expressed in E. coli, spanning Val22-Pro98. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Система экспрессии	E. coli
Номер доступа	P02778
Длина белка	Val22-Pro98
Применения	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Виды	Homo sapiens (Human)
Характер	Recombinant
Уровень эндотоксинов	Please contact with the lab for this information.
Чистота	>90% as determined by SDS-PAGE.
Прогнозируемая молекулярная масса	36.83 kDa
Форма	Lyophilized
Буфер хранения	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Реконституция	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Доставка	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Альтернативные названия	10 kDa interferon gamma-induced protein, C-X-C motif chemokine 10, CXCL10, CXCL10(1-73), Gamma-IP10, INP10, IP-10, SCYB10, Small-inducible cytokine B10
Фон	C-X-C motif chemokine 10 is a ~10 kDa protein. Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects. Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites. Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium production and actin reorganization. In turn, recruitment of activated Th1 lymphocytes occurs at sites of inflammation. Activation of the CXCL10/CXCR3 axis also plays an important role in neurons in response to brain injury for activating microglia, the resident macrophage population of the central nervous system, and directing them to the lesion site. 1. Romagnani, P. et al. (2001) Blood 97, 601-7. PMID: 11157474 2. Sidahmed, AM. et al. (2012) Cytokine 59, 433-41. PMID: 22652417 3. Angiolillo, AL. et al. (1995) The Journal of experimental medicine 182, 155-62. PMID: 7540647 4. Smit, MJ. et al. (2003) Blood 102, 1959-65. PMID: 12750173 5. Gao, JM. et al. (2009) Acta pharmacologica Sinica 30, 193-201. PMID: 19151743 6. Cheeran, MC. et al. (2003) Journal of virology 77, 4502-15. PMID: 12663757
Примечание	For research use only