中文
English
한국어
日本語
Español
Français
Русский
| カタログ番号 | HD015012 |
|---|---|
| 説明 |
Recombinant Human CYP2B6 Protein, N-His (HD015012) expressed in E. coli, spanning Gly41-Arg491. Purity: >90% by SDS-PAGE.
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | P20813 |
| タンパク質長 | Gly41-Arg491 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 予測分子量 | 54.11 kDa |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | 1,4-cineole 2-exo-monooxygenase, CYP2B6, CYPIIB6, Cytochrome P450 2B6, Cytochrome P450 IIB1, EC:1.14.13.- |
| 背景 | Cytochrome P450 2B6 is a ~56 kDa protein. A cytochrome P450 monooxygenase involved in the metabolism of endocannabinoids and steroids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the epoxidation of double bonds of arachidonoylethanolamide (anandamide) to 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs), potentially modulating endocannabinoid system signaling. Hydroxylates steroid hormones, including testosterone at C-16 and estrogens at C-2. Plays a role in the oxidative metabolism of xenobiotics, including plant lipids and drugs. 1. Lee, AJ. et al. (2003) Endocrinology 144, 3382-98. PMID: 12865317 2. Sridar, C. et al. (2011) Drug metabolism and disposition: the biological fate of chemicals 39, 782-8. PMID: 21289075 3. Miyazawa, M. et al. (2001) Xenobiotica; the fate of foreign compounds in biological systems 31, 713-23. PMID: 11695850 4. Shah, MB. et al. (2012) Biochemistry 51, 7225-38. PMID: 22909231 |
| 注意事項 | For research use only |
+86-027-65523339
中国武漢市深敦寺路666号C棟、武漢、430206
