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| カタログ番号 | HD745012 |
|---|---|
| 説明 |
Recombinant Human CYP2J2 Protein, N-His (HD745012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | P51589 |
| タンパク質長 | Gly54-Val502 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | Albendazole monooxygenase (hydroxylating), Albendazole monooxygenase (sulfoxide-forming), Arachidonic acid epoxygenase, CYP2J2, CYPIIJ2, Cytochrome P450 2J2, EC:1.14.14.-, EC:1.14.14.73, EC:1.14.14.74, EC:5.4.4.7, Hydroperoxy icosatetraenoate isomerase |
| 背景 | Cytochrome P450 2J2 is a ~57 kDa protein. A cytochrome P450 monooxygenase involved in the metabolism of polyunsaturated fatty acids (PUFA) in the cardiovascular system. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the epoxidation of double bonds of PUFA. Converts arachidonic acid to four regioisomeric epoxyeicosatrienoic acids (EpETrE), likely playing a major role in the epoxidation of endogenous cardiac arachidonic acid pools. In endothelial cells, participates in eicosanoids metabolism by converting hydroperoxide species into hydroxy epoxy metabolites. 1. Lucas, D. et al. (2010) Journal of lipid research 51, 1125-33. PMID: 19965576 2. Wu, S. et al. (1996) The Journal of biological chemistry 271, 3460-8. PMID: 8631948 3. Chawengsub, Y. et al. (2009) The Journal of biological chemistry 284, 31280-90. PMID: 19737933 4. Lee, CA. et al. (2010) Drug metabolism and disposition: the biological fate of chemicals 38, 347-56. PMID: 19923256 5. Wu, Z. et al. (2013) Antimicrobial agents and chemotherapy 57, 5448-56. PMID: 23959307 |
| 注意事項 | For research use only |
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