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| カタログ番号 | HD747012 |
|---|---|
| 説明 |
Recombinant Human DDX39A Protein, N-His (HD747012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | O00148 |
| タンパク質長 | Arg47-Arg427 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | ATP-dependent RNA helicase DDX39A, DDX39, DDX39A, DEAD box protein 39, EC:3.6.4.13, Nuclear RNA helicase URH49 |
| 背景 | ATP-dependent RNA helicase DDX39A is a ~49 kDa protein. Helicase that plays an essential role in mRNA export and is involved in multiple steps in RNA metabolism including alternative splicing. Regulates nuclear mRNA export to the cytoplasm through association with ECD. Also involved in spliceosomal uridine-rich small nuclear RNA (U snRNA) export by stimulating the RNA binding of adapter PHAX. Plays a role in the negative regulation of type I IFN production by increasing the nuclear retention of antiviral transcripts and thus reducing their protein expression. Independently of the interferon pathway, plays an antiviral role against alphaviruses by binding to a 5' conserved sequence element in the viral genomic RNA. 1. Saleem, I. et al. (2021) Molecular and cellular biology 41, e0010321. PMID: 33941617 2. Banerjee, S. et al. (2024) Nucleic acids research 52, 8534-8551. PMID: 38801080 3. Taniguchi, I. et al. (2024) Nucleic acids research 52, 10668-10682. PMID: 39011894 4. Shi, P. et al. (2020) Journal of immunology (Baltimore, Md. : 1950) 205, 168-180. PMID: 32393512 5. Tapescu, I. et al. (2023) Molecular cell 83, 4174-4189.e7. PMID: 37949067 |
| 注意事項 | For research use only |
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