

| Número de catálogo | HD865012 |
|---|---|
| Descripción |
Recombinant Human DGUOK Protein, N-His (HD865012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| Sistema de expresión | E. coli |
| Número de acceso | Q16854 |
| Longitud de proteína | Arg40-Leu277 |
| Aplicaciones | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| Especies | Homo sapiens (Human) |
| Naturaleza | Recombinant |
| Nivel de endotoxinas | Please contact with the lab for this information. |
| Pureza | >90% as determined by SDS-PAGE. |
| Forma | Lyophilized |
| Buffer de almacenamiento | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote. |
| Reconstitución | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Envío | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Estabilidad y almacenamiento | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Nombres alternativos | DGK, DGUOK, Deoxyadenosine kinase, mitochondrial, Deoxyguanosine kinase, mitochondrial, EC:2.7.1.113, EC:2.7.1.76 |
| Fondo | Deoxyguanosine kinase, mitochondrial is a ~32 kDa protein. Phosphorylates deoxyguanosine and deoxyadenosine in the mitochondrial matrix, with the highest efficiency for deoxyguanosine. In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on DGUOK and TK2. Phosphorylates certain nucleoside analogs. Widely used as target of antiviral and chemotherapeutic agents. 1. Saada, A. et al. (2001) Nature genetics 29, 342-4. PMID: 11687801 2. Mousson de Camaret, B. et al. (2007) The Biochemical journal 402, 377-85. PMID: 17073823 3. Ronchi, D. et al. (2012) Brain : a journal of neurology 135, 3404-15. PMID: 23043144 4. Johansson, M. et al. (1996) Proceedings of the National Academy of Sciences of the United States of America 93, 7258-62. PMID: 8692979 5. Wang, L. et al. (1996) FEBS letters 390, 39-43. PMID: 8706825 |
| Nota | For research use only |
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