Human DNAJB12 Recombinant Protein (N-His) (HA046022)

Name: Human DNAJB12 Recombinant Protein (N-His)
Brand: abinScience
SKU: HA046022
Price: 211 USD
Availability: InStock

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Каталожный номер	HA046022
Описание	Recombinant Human DNAJB12 Protein, N-His (HA046022) expressed in E. coli, spanning Thr95-Gly211. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Система экспрессии	E. coli
Номер доступа	Q9NXW2
Длина белка	Thr95-Gly211
Применения	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Виды	Homo sapiens (Human)
Характер	Recombinant
Уровень эндотоксинов	Please contact with the lab for this information.
Чистота	>90% as determined by SDS-PAGE.
Прогнозируемая молекулярная масса	15.30 kDa
Форма	Lyophilized
Буфер хранения	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Реконституция	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Доставка	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Альтернативные названия	DNAJB12, DnaJ homolog subfamily B member 12
Фон	DnaJ homolog subfamily B member 12 is a ~41 kDa protein. Acts as a co-chaperone with HSPA8/Hsc70; required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD) pathway. Acts by determining HSPA8/Hsc70's ATPase and polypeptide-binding activities. Can also act independently of HSPA8/Hsc70: together with DNAJB14, acts as a chaperone that promotes maturation of potassium channels KCND2 and KCNH2 by stabilizing nascent channel subunits and assembling them into tetramers. While stabilization of nascent channel proteins is dependent on HSPA8/Hsc70, the process of oligomerization of channel subunits is independent of HSPA8/Hsc70. When overexpressed, forms membranous structures together with DNAJB14 and HSPA8/Hsc70 within the nucleus; the role of these structures, named DJANGOs, is still unclear. 1. Grove, DE. et al. (2011) Molecular biology of the cell 22, 301-14. PMID: 21148293 2. Yamamoto, YH. et al. (2010) Cell structure and function 35, 107-16. PMID: 21150129 3. Li, K. et al. (2017) Molecular cell 65, 52-65. PMID: 27916661 4. Goodwin, EC. et al. (2014) PloS one 9, e94322. PMID: 24732912
Примечание	For research use only

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Human DNAJB12 Recombinant Protein (N-His).pdf

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