Human DNAJC10 Recombinant Protein (N-His) (HD135012)

Name: Human DNAJC10 Recombinant Protein (N-His)
Brand: abinScience
SKU: HD135012
Price: 211 USD
Availability: InStock

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Numéro de catalogue	HD135012
Description	Recombinant Human DNAJC10 Protein, N-His (HD135012) expressed in E. coli, spanning Ser354-Asn555. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Système d'expression	E. coli
Numéro d'accès	Q8IXB1
Longueur de protéine	Ser354-Asn555
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Espèces	Homo sapiens (Human)
Nature	Recombinant
Niveau d'endotoxines	Please contact with the lab for this information.
Pureté	>90% as determined by SDS-PAGE.
Masse moléculaire prédite	25.47 kDa
Forme	Lyophilized
Tampon de stockage	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Expédition	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs	DNAJC10, DnaJ homolog subfamily C member 10, EC:1.8.4.-, ER-resident protein ERdj5, ERDJ5, ERdj5, Endoplasmic reticulum DNA J domain-containing protein 5, MTHr, Macrothioredoxin
Contexte	Endoplasmic reticulum disulfide reductase DNAJC10 is a ~91 kDa protein. Endoplasmic reticulum disulfide reductase that collaborates directly with the chaperone BIP/HSPA5 (GRP78) to maintain protein quality control by facilitating either the correct folding or the targeted degradation of misfolded proteins. Essential for efficient maturation of newly synthesized polypeptides in the endoplasmic reticulum, binds to substrate proteins and specifically catalyzes the reduction and removal of improper (non-native) disulfide bonds during the folding process. In endoplasmic reticulum-associated degradation (ERAD), DNAJC10 reduces incorrect disulfide bonds specifically in misfolded glycoproteins that have been recognized by EDEM1, a key component of the ERAD pathway, thereby enabling their retrotranslocation and degradation. Promotes apoptotic signaling pathway in response to endoplasmic reticulum stress. 1. Cunnea, PM. et al. (2003) The Journal of biological chemistry 278, 1059-66. PMID: 12411443 2. Oka, OB. et al. (2013) Molecular cell 50, 793-804. PMID: 23769672 3. Cai, X. et al. (2023) The Journal of biological chemistry 299, 105274. PMID: 37739037 4. Dong, M. et al. (2008) Molecular biology of the cell 19, 2620-30. PMID: 18400946 5. Thomas, CG. et al. (2009) The Journal of biological chemistry 284, 6282-90. PMID: 19122239
Note	For research use only

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Human DNAJC10 Recombinant Protein (N-His).pdf

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