Human DYRK1A Recombinant Protein (N-His) (HD205012)

Name: Human DYRK1A Recombinant Protein (N-His)
Brand: abinScience
SKU: HD205012
Price: 211 USD
Availability: InStock

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Número de catálogo	HD205012
Descripción	Recombinant Human DYRK1A Protein, N-His (HD205012) expressed in E. coli, spanning Gly152-Lys480. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Sistema de expresión	E. coli
Número de acceso	Q13627
Longitud de proteína	Gly152-Lys480
Aplicaciones	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Especies	Homo sapiens (Human)
Naturaleza	Recombinant
Nivel de endotoxinas	Please contact with the lab for this information.
Pureza	>90% as determined by SDS-PAGE.
Peso molecular predicho	40.42 kDa
Forma	Lyophilized
Buffer de almacenamiento	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Reconstitución	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Envío	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativos	DYRK, DYRK1A, Dual specificity YAK1-related kinase, Dual specificity tyrosine-phosphorylation-regulated kinase 1A, EC:2.7.11.23, EC:2.7.12.1, HP86, MNB, MNBH, Protein kinase minibrain homolog, hMNB
Fondo	Dual specificity tyrosine-phosphorylation-regulated kinase 1A is a ~85 kDa protein. Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Exhibits a substrate preference for proline at position P+1 and arginine at position P-3. Plays an important role in double-strand breaks (DSBs) repair following DNA damage. Mechanistically, phosphorylates RNF169 and increases its ability to block accumulation of TP53BP1 at the DSB sites thereby promoting homologous recombination repair (HRR). Also acts as a positive regulator of transcription by acting as a CTD kinase that mediates phosphorylation of the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A. 1. Ogawa, Y. et al. (2010) Nature communications 1, 86. PMID: 20981014 2. Papadopoulos, C. et al. (2011) The Journal of biological chemistry 286, 5494-505. PMID: 21127067 3. Soundararajan, M. et al. (2013) Structure (London, England : 1993) 21, 986-96. PMID: 23665168 4. Menon, VR. et al. (2019) Cell cycle (Georgetown, Tex.) 18, 531-551. PMID: 30773093 5. Shindoh, N. et al. (1996) Biochemical and biophysical research communications 225, 92-9. PMID: 8769099 6. Guard, SE. et al. (2019) Scientific reports 9, 6539. PMID: 31024071 7. Di Vona, C. et al. (2015) Molecular cell 57, 506-20. PMID: 25620562 8. Lu, H. et al. (2018) Nature 558, 318-323. PMID: 29849146
Nota	For research use only

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Datasheet

Human DYRK1A Recombinant Protein (N-His).pdf

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