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| カタログ番号 | HD804012 |
|---|---|
| 説明 |
Recombinant Human FOXK2 Protein, N-His (HD804012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | Q01167 |
| タンパク質長 | Ala36-Ser159&Ser262-Arg348 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | FOXK2, Forkhead box protein K2, G/T-mismatch specific binding protein, ILF, ILF1, Interleukin enhancer-binding factor 1, nGTBP |
| 背景 | Forkhead box protein K2 is a ~69 kDa protein. Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis and autophagy. Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context. Together with FOXK1, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen. Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4. Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate. 1. El-Mergawy, R. et al. (2024) The Journal of biological chemistry 300, 107359. PMID: 38735474 2. Ji, Z. et al. (2012) Molecular and cellular biology 32, 385-98. PMID: 22083952 3. Okino, Y. et al. (2015) The Journal of biological chemistry 290, 1580-91. PMID: 25451922 4. Fujii, Y. et al. (2010) Journal of biochemistry 147, 705-9. PMID: 20097901 5. Li, C. et al. (1992) Genomics 13, 665-71. PMID: 1339390 6. Wang, W. et al. (2015) Developmental cell 32, 707-18. PMID: 25805136 7. Li, C. et al. (1991) Proceedings of the National Academy of Sciences of the United States of America 88, 7739-43. PMID: 1909027 8. Baymaz, HI. et al. (2014) Proteomics 14, 2179-89. PMID: 24634419 9. Campagne, A. et al. (2019) Nature communications 10, 348. PMID: 30664650 |
| 注意事項 | For research use only |
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