Human FoxP3 Recombinant Protein (N-His) (HV388042)

Name: Human FoxP3 Recombinant Protein (N-His)
Brand: abinScience
SKU: HV388042
Price: 211 USD
Availability: InStock

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Número de catálogo	HV388042
Descripción	Recombinant Human FOXP3 Protein, N-His (HV388042) expressed in E. coli, spanning Ser304-Pro431. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Sistema de expresión	E. coli
Número de acceso	Q9BZS1
Longitud de proteína	Ser304-Pro431
Aplicaciones	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Especies	Homo sapiens (Human)
Naturaleza	Recombinant
Nivel de endotoxinas	Please contact with the lab for this information.
Pureza	>90% as determined by SDS-PAGE.
Peso molecular predicho	17.70 kDa
Forma	Lyophilized
Buffer de almacenamiento	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Reconstitución	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Envío	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativos	FOXP3, Forkhead box protein P3, Forkhead box protein P3 41 kDa form, Forkhead box protein P3, C-terminally processed, IPEX, Scurfin
Fondo	Forkhead box protein P3 is a ~47 kDa protein. Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells. Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases. The suppressive activity of Treg involves the coordinate activation of many genes, including CTLA4 and TNFRSF18 by FOXP3 along with repression of genes encoding cytokines such as interleukin-2 (IL2) and interferon-gamma (IFNG). Inhibits cytokine production and T-cell effector function by repressing the activity of two key transcription factors, RELA and NFATC2. 1. Ono, M. et al. (2007) Nature 446, 685-9. PMID: 17377532 2. Bandukwala, HS. et al. (2011) Immunity 34, 479-91. PMID: 21458306 3. Vent-Schmidt, J. et al. (2014) International reviews of immunology 33, 110-28. PMID: 23947341 4. Passerini, L. et al. (2014) International reviews of immunology 33, 129-45. PMID: 24354325 5. Ramsdell, F. et al. (2014) Nature reviews. Immunology 14, 343-9. PMID: 24722479 6. Xiao, Y. et al. (2014) Cell reports 7, 1471-1480. PMID: 24835996 7. Becher, J. et al. (2018) Developmental cell 47, 592-607.e6. PMID: 30513302 8. Yang, J. et al. (2020) EMBO reports 21, e50308. PMID: 32644293 9. McMurchy, AN. et al. (2013) Blood 121, 1265-75. PMID: 23169781 10. Bettelli, E. et al. (2005) Proceedings of the National Academy of Sciences of the United States of America 102, 5138-43. PMID: 15790681
Nota	For research use only

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Datasheet

Human FoxP3 Recombinant Protein (N-His).pdf

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