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| カタログ番号 | HD812012 |
|---|---|
| 説明 |
Recombinant Human FPR2 Protein, N-GST & C-His (HD812012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | P25090 |
| タンパク質長 | Glu2-Ile27&Ser84-Leu100&Lys227-Val242&Gln307-Met351 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | ALX, FMLP-R-I, FMLP-related receptor I, FPR2, FPRH1, FPRL1, Formyl peptide receptor-like 1, HM63, LXA4 receptor, LXA4R, Lipoxin A4 receptor, N-formyl peptide receptor 2, RFP |
| 背景 | N-formyl peptide receptor 2 is a ~38 kDa protein. Pattern recognition G protein-coupled receptor (GPCR) that recognizes peptides with N-terminal formyl methionine, which are derived from invading pathogens or host mitochondria as pathogen or damage-associated molecular patterns (PAMPs and DAMPs). Preferentially recognizes longer peptides or peptides with specific sequences such as the phenol-soluble modulin (PSM) family of formylated peptide toxins produced by Staphylococcus aureus. Ligand binding causes a conformation change that triggers signaling via G(i)/GNAI1 inhibiting adenylate cyclase activity, leading to decreased intracellular cAMP levels. In addition, can recognize a variety of chemically distinct endogenous ligands including proteins and lipids besides formylpeptides and thereby plays multiple roles in inflammation. Acts as a receptor for the chemokine-like protein FAM19A5, mediating FAM19A5-stimulated macrophage chemotaxis and the inhibitory effect on TNFSF11/RANKL-induced osteoclast differentiation. 1. Ye, RD. et al. (1992) Biochemical and biophysical research communications 184, 582-9. PMID: 1374236 2. Bufe, B. et al. (2015) The Journal of biological chemistry 290, 7369-87. PMID: 25605714 3. Zhuang, Y. et al. (2022) Nature communications 13, 1054. PMID: 35217703 4. Zhao, Y. et al. (2018) Cellular microbiology 20, e12941. PMID: 30098280 5. Lin, H. et al. (2025) Science (New York, N.Y.) 388, eado4188. PMID: 40080544 6. Yazawa, H. et al. (2001) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 15, 2454-62. PMID: 11689470 7. Zhu, Y. et al. (2022) Nature communications 13, 1775. PMID: 35365641 |
| 注意事項 | For research use only |
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