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| カタログ番号 | HD751012 |
|---|---|
| 説明 |
Recombinant Human GABRG2 Protein, N-His (HD751012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | P18507 |
| タンパク質長 | Thr90-Arg271 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | GABA(A) receptor subunit gamma-2, GABAAR subunit gamma-2, GABRG2, Gamma-aminobutyric acid receptor subunit gamma-2 |
| 背景 | Gamma-aminobutyric acid receptor subunit gamma-2 is a ~55 kDa protein. Gamma subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain. GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient. Gamma-2/GABRG2-containing GABAARs are found at both synaptic and extrasynaptic sites. Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission. 1. Caraiscos, VB. et al. (2004) Proceedings of the National Academy of Sciences of the United States of America 101, 3662-7. PMID: 14993607 2. Ranna, M. et al. (2006) BMC pharmacology 6, 1. PMID: 16412217 3. Fuchs, C. et al. (2013) The European journal of neuroscience 38, 3146-58. PMID: 23909897 4. Pritchett, DB. et al. (1989) Nature 338, 582-5. PMID: 2538761 5. Brown, LE. et al. (2014) Journal of visualized experiments : JoVE, e52115. PMID: 25489750 6. Shen, D. et al. (2017) Brain : a journal of neurology 140, 49-67. PMID: 27864268 7. Zhu, S. et al. (2018) Nature 559, 67-72. PMID: 29950725 8. Laverty, D. et al. (2019) Nature 565, 516-520. PMID: 30602789 |
| 注意事項 | For research use only |
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