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| カタログ番号 | HD217012 |
|---|---|
| 説明 |
Recombinant Human GCKR Protein, N-His (HD217012) expressed in E. coli, spanning Met1-Asn503. Purity: >90% by SDS-PAGE.
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | Q14397 |
| タンパク質長 | Met1-Asn503 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 予測分子量 | 57.44 kDa |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | GCKR, GKRP, Glucokinase regulator, Glucokinase regulatory protein |
| 背景 | Glucokinase regulatory protein is a ~68 kDa protein. Regulates glucokinase (GCK) by forming an inactive complex with this enzyme. Acts by promoting GCK recruitment to the nucleus, possibly to provide a reserve of GCK that can be quickly released in the cytoplasm after a meal. The affinity of GCKR for GCK is modulated by fructose metabolites: GCKR with bound fructose 6-phosphate has increased affinity for GCK, while GCKR with bound fructose 1-phosphate has strongly decreased affinity for GCK and does not inhibit GCK activity. 1. Pautsch, A. et al. (2013) Biochemistry 52, 3523-31. PMID: 23621087 2. Choi, JM. et al. (2013) Proceedings of the National Academy of Sciences of the United States of America 110, 10171-6. PMID: 23733961 3. de la Iglesia, N. et al. (1999) FEBS letters 456, 332-8. PMID: 10456334 |
| 注意事項 | For research use only |
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