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| カタログ番号 | HD909012 |
|---|---|
| 説明 |
Recombinant Human GFI1 Protein, N-His (HD909012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | Q99684 |
| タンパク質長 | Lys256-Lys422 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | GFI1, Growth factor independent protein 1, ZNF163, Zinc finger protein 163, Zinc finger protein Gfi-1 |
| 背景 | Zinc finger protein Gfi-1 is a ~45 kDa protein. Transcription repressor essential for hematopoiesis. Functions in a cell-context and development-specific manner. Binds to 5'-TAAATCAC[AT]GCA-3' in the promoter region of a large number of genes. Component of several complexes, including the EHMT2-GFI1-HDAC1, AJUBA-GFI1-HDAC1 and RCOR-GFI-KDM1A-HDAC complexes, that suppress, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Regulates neutrophil differentiation, promotes proliferation of lymphoid cells, and is required for granulocyte development. 1. Rödel, B. et al. (2000) The EMBO journal 19, 5845-55. PMID: 11060035 2. Dahl, R. et al. (2007) The Journal of biological chemistry 282, 6473-83. PMID: 17197705 3. Marteijn, JA. et al. (2007) Blood 110, 3128-35. PMID: 17646546 4. Montoya-Durango, DE. et al. (2008) The Journal of biological chemistry 283, 32056-65. PMID: 18805794 5. Basu, S. et al. (2009) Proceedings of the National Academy of Sciences of the United States of America 106, 1433-8. PMID: 19164764 6. Liu, Q. et al. (2010) Oncogene 29, 2843-52. PMID: 20190815 7. Zweidler-Mckay, PA. et al. (1996) Molecular and cellular biology 16, 4024-34. PMID: 8754800 10. Sharif-Askari, E. et al. (2010) Molecular and cellular biology 30, 3929-42. PMID: 20547752 |
| 注意事項 | For research use only |
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