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| カタログ番号 | HD979012 |
|---|---|
| 説明 |
Recombinant Human GGCX Protein, N-His (HD979012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | P38435 |
| タンパク質長 | Asn388-Gly709 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | EC:4.1.1.90, GC, GGCX, Gamma-glutamyl carboxylase, Peptidyl-glutamate 4-carboxylase, VKGC, Vitamin K gamma glutamyl carboxylase, Vitamin K-dependent gamma-carboxylase |
| 背景 | Vitamin K-dependent gamma-carboxylase is a ~87 kDa protein. Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant epoxidation of vitamin K hydroquinone to vitamin K epoxide. Couples epoxidation and carboxylation in the same active site. Catalyzes gamma-carboxylation of blood coagulation factors (F2, F7, F9 and F10) and anticoagulants such as PROC, which are essential for thrombosis. Catalyzes gamma-carboxylation of osteocalcin/BGLAP, which is essential for bone metabolism. Catalyzes gamma-carboxylation of matrix Gla protein (MGP) and other transmembrane gamma-Gla proteins such as PRRG2, which are essential for calcium homeostasis and haemostasis. 1. Rishavy, MA. et al. (2006) Biochemistry 45, 13239-48. PMID: 17073445 2. Wang, R. et al. (2025) Nature 639, 808-815. PMID: 39880952 3. Cao, Q. et al. (2025) Nature 639, 816-824. PMID: 39880037 |
| 注意事項 | For research use only |
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