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| カタログ番号 | HC924012 |
|---|---|
| 説明 |
Recombinant Human GNA15 Protein, N-His (HC924012) expressed in E. coli, spanning Glu42-Leu374. Purity: >90% by SDS-PAGE.
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | P30679 |
| タンパク質長 | Glu42-Leu374 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 予測分子量 | 40.96 kDa |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | Epididymis tissue protein Li 17E, G alpha-15, G alpha-16, G-protein subunit alpha-15, G-protein subunit alpha-16, GNA15, GNA16, Guanine nucleotide-binding protein subunit alpha-15, Guanine nucleotide-binding protein subunit alpha-16 |
| 背景 | Guanine nucleotide-binding protein subunit alpha-15 is a ~43 kDa protein. Member of the G-protein alpha subunit family that plays a crucial role in intracellular signaling. Functions as a molecular switch, transducing signals from G protein-coupled receptors (GPCRs) to downstream effectors. In collaboration with the adapter protein TTC1, promotes HRAS activation and ERK1/2 phosphorylation independently of phospholipase Cbeta signaling. Also initiates EMR2-mediated signaling, leading to activation of Akt, MAPK, and NF-kappa-B, which in turn drives macrophage differentiation and inflammatory responses. 1. Marty, C. et al. (2003) Molecular and cellular biology 23, 3847-58. PMID: 12748287 2. Liu, AM. et al. (2010) Cellular signalling 22, 1448-58. PMID: 20639119 3. I, KY. et al. (2017) Frontiers in immunology 8, 373. PMID: 28421075 |
| 注意事項 | For research use only |
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