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| カタログ番号 | HD326012 |
|---|---|
| 説明 |
Recombinant Human GRHL2 Protein, N-His (HD326012) expressed in E. coli, spanning Gln274-Cys417. Purity: >90% by SDS-PAGE.
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | Q6ISB3 |
| タンパク質長 | Gln274-Cys417 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 予測分子量 | 19.20 kDa |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | BOM, Brother of mammalian grainyhead, GRHL2, Grainyhead-like protein 2 homolog, TFCP2L3, Transcription factor CP2-like 3 |
| 背景 | Grainyhead-like protein 2 homolog is a ~71 kDa protein. Transcription factor playing an important role in primary neurulation and in epithelial development. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' acting as an activator and repressor on distinct target genes. During embryogenesis, plays unique and cooperative roles with GRHL3 in establishing distinct zones of primary neurulation. Essential for closure 3 (rostral end of the forebrain), functions cooperatively with GRHL3 in closure 2 (forebrain/midbrain boundary) and posterior neuropore closure. Regulates epithelial morphogenesis acting as a target gene-associated transcriptional activator of apical junctional complex components. 1. Petrof, G. et al. (2014) American journal of human genetics 95, 308-14. PMID: 25152456 2. Ming, Q. et al. (2018) Nucleic acids research 46, 2082-2095. PMID: 29309642 3. Kang, X. et al. (2009) Oncogene 28, 565-74. PMID: 19015635 4. Chen, W. et al. (2010) The Journal of biological chemistry 285, 40852-63. PMID: 20938050 5. Chen, W. et al. (2012) Cell death & disease 3, e450. PMID: 23254293 |
| 注意事項 | For research use only |
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