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| カタログ番号 | HD260012 |
|---|---|
| 説明 |
Recombinant Human GUK1 Protein, N-His (HD260012) expressed in E. coli, spanning Met1-Ala197. Purity: >90% by SDS-PAGE.
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | Q16774 |
| タンパク質長 | Met1-Ala197 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 予測分子量 | 23.89 kDa |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | EC:2.7.4.8, GMK, GMP kinase, GMPK, GUK1, Guanylate kinase, Guanylate kinase 1 |
| 背景 | Guanylate kinase is a ~21 kDa protein. Catalyzes the phosphorylation of GMP to GDP. Essential enzyme for recycling GMP and indirectly, cyclic GMP (cGMP). Involved in the cGMP metabolism in photoreceptors. It may also have a role in the survival and growth progression of some tumors. In addition to its physiological role, GUK1 is essential for converting prodrugs used for the treatment of cancers and viral infections into their pharmacologically active metabolites, most notably acyclovir, ganciclovir, and 6-thioguanine and its closely related analog 6-mercaptopurine. 1. Khan, N. et al. (2019) The Journal of biological chemistry 294, 11920-11933. PMID: 31201273 2. Miller, RL. et al. (1977) Biochemical pharmacology 26, 1573-6. PMID: 197968 3. Miller, WH. et al. (1980) The Journal of biological chemistry 255, 7204-7. PMID: 6248551 4. Field, AK. et al. (1983) Proceedings of the National Academy of Sciences of the United States of America 80, 4139-43. PMID: 6306664 |
| 注意事項 | For research use only |
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