Human GUK1 Recombinant Protein (N-His) (HD260012)

Name: Human GUK1 Recombinant Protein (N-His)
Brand: abinScience
SKU: HD260012
Price: 211 USD
Availability: InStock

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50ug
100ug
1mg

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Обзор
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Даташит
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Обзор

Каталожный номер	HD260012
Описание	Recombinant Human GUK1 Protein, N-His (HD260012) expressed in E. coli, spanning Met1-Ala197. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Система экспрессии	E. coli
Номер доступа	Q16774
Длина белка	Met1-Ala197
Применения	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Виды	Homo sapiens (Human)
Характер	Recombinant
Уровень эндотоксинов	Please contact with the lab for this information.
Чистота	>90% as determined by SDS-PAGE.
Прогнозируемая молекулярная масса	23.89 kDa
Форма	Lyophilized
Буфер хранения	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Реконституция	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Доставка	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Альтернативные названия	EC:2.7.4.8, GMK, GMP kinase, GMPK, GUK1, Guanylate kinase, Guanylate kinase 1
Фон	Guanylate kinase is a ~21 kDa protein. Catalyzes the phosphorylation of GMP to GDP. Essential enzyme for recycling GMP and indirectly, cyclic GMP (cGMP). Involved in the cGMP metabolism in photoreceptors. It may also have a role in the survival and growth progression of some tumors. In addition to its physiological role, GUK1 is essential for converting prodrugs used for the treatment of cancers and viral infections into their pharmacologically active metabolites, most notably acyclovir, ganciclovir, and 6-thioguanine and its closely related analog 6-mercaptopurine. 1. Khan, N. et al. (2019) The Journal of biological chemistry 294, 11920-11933. PMID: 31201273 2. Miller, RL. et al. (1977) Biochemical pharmacology 26, 1573-6. PMID: 197968 3. Miller, WH. et al. (1980) The Journal of biological chemistry 255, 7204-7. PMID: 6248551 4. Field, AK. et al. (1983) Proceedings of the National Academy of Sciences of the United States of America 80, 4139-43. PMID: 6306664
Примечание	For research use only

Изображения

Ссылки

Даташит

Human GUK1 Recombinant Protein (N-His).pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Рекомбинантные Белки

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