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| カタログ番号 | HD762012 |
|---|---|
| 説明 |
Recombinant Human HEMK2 Protein, C-His (HD762012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | Q9Y5N5 |
| タンパク質長 | Met1-Ser214 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | C21orf127, EC:2.1.1.-, HEMK2, HemK methyltransferase family member 2, KMT9, Lysine N-methyltransferase 9, M.HsaHemK2P, Methylarsonite methyltransferase N6AMT1, Methyltransferase HEMK2, Methyltransferase N6AMT1, N6AMT1, PRED28, Protein N(5)-glutamine methyltransferase |
| 背景 | Methyltransferase HEMK2 is a ~22 kDa protein. Methyltransferase that can methylate proteins and, to a lower extent, arsenic. Catalytic subunit of a heterodimer with TRMT112, which monomethylates 'Lys-12' of histone H4 (H4K12me1), a modification present at the promoters of numerous genes encoding cell cycle regulators. Catalytic subunit of a heterodimer with TRMT112, which catalyzes N5-methylation of Glu residue of proteins with a Gly-Gln-Xaa-Xaa-Xaa-Arg motif. Methylates ETF1 on 'Gln-185'; ETF1 needs to be complexed to ERF3 in its GTP-bound form to be efficiently methylated. May also play a role in the modulation of arsenic-induced toxicity by mediating the conversion of monomethylarsonous acid (3+) into the less toxic dimethylarsonic acid. 1. Figaro, S. et al. (2008) FEBS letters 582, 2352-6. PMID: 18539146 2. Ren, X. et al. (2011) Environmental health perspectives 119, 771-7. PMID: 21193388 3. Xiao, CL. et al. (2018) Molecular cell 71, 306-318.e7. PMID: 30017583 4. Metzger, E. et al. (2019) Nature structural & molecular biology 26, 361-371. PMID: 31061526 5. Li, W. et al. (2019) Cell discovery 5, 51. PMID: 31636962 6. Woodcock, CB. et al. (2019) Cell discovery 5, 50. PMID: 31632689 7. Liu, P. et al. (2010) Molecular and cellular biology 30, 4245-53. PMID: 20606008 |
| 注意事項 | For research use only |
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