

| Numéro de catalogue | HD167012 |
|---|---|
| Description |
Recombinant Human HHEX Protein, N-His-KSI (HD167012) expressed in E. coli, spanning Gln2-Gly270. Purity: >90% by SDS-PAGE.
Highlights
|
| Système d'expression | E. coli |
| Numéro d'accès | Q03014 |
| Longueur de protéine | Gln2-Gly270 |
| Applications | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| Espèces | Homo sapiens (Human) |
| Nature | Recombinant |
| Niveau d'endotoxines | Please contact with the lab for this information. |
| Pureté | >90% as determined by SDS-PAGE. |
| Masse moléculaire prédite | 45.65 kDa |
| Forme | Lyophilized |
| Tampon de stockage | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
| Reconstitution | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Expédition | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Stabilité et stockage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Noms alternatifs | HEX, HHEX, Hematopoietically-expressed homeobox protein HHEX, Homeobox protein HEX, Homeobox protein PRH, PRH, PRHX, Proline-rich homeodomain protein |
| Contexte | Hematopoietically-expressed homeobox protein HHEX is a ~30 kDa protein. Recognizes the DNA sequence 5'-ATTAA-3'. Transcriptional repressor. Activator of WNT-mediated transcription in conjunction with CTNNB1. Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL. Inhibits EIF4E-mediated mRNA nuclear export. 1. Marfil, V. et al. (2010) The Journal of biological chemistry 285, 5726-37. PMID: 20028982 2. Topisirovic, I. et al. (2003) The EMBO journal 22, 689-703. PMID: 12554669 3. Bedford, FK. et al. (1993) Nucleic acids research 21, 1245-9. PMID: 8096636 |
| Note | For research use only |
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