Human Histone H1.2 Recombinant Protein (N-GST & C-His) (HA105012)

Name: Human Histone H1.2 Recombinant Protein (N-GST & C-His)
Brand: abinScience
SKU: HA105012
Price: 211 USD
Availability: InStock

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Numéro de catalogue	HA105012
Description	Recombinant Human Histone H1.2 Protein, N-GST & C-His (HA105012) expressed in E. coli, spanning Ser41-Asn108. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Système d'expression	E. coli
Numéro d'accès	P16403
Longueur de protéine	Ser41-Asn108
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Espèces	Homo sapiens (Human)
Nature	Recombinant
Niveau d'endotoxines	Please contact with the lab for this information.
Pureté	>90% as determined by SDS-PAGE.
Masse moléculaire prédite	35.12 kDa
Forme	Lyophilized
Tampon de stockage	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Expédition	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs	H1-2, H1F2, HIST1H1C, Histone H1.2, Histone H1c, Histone H1d, Histone H1s-1
Contexte	Histone H1.2 is a ~21 kDa protein. Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histone H1-2 is required for the condensation of nucleosome chains into higher-order structured fibers. Compared to other histone H1 variants, H1-2 plays an essnetial role in nucleosome condensation: its absence leads to global chromatin decompaction, which is not observed when depleting other histone H1 variants. Histone H1-2 also acts as a histone reader: specifically recognizes and binds histone H3 trimethylated at 'lys-27' (H3K27me3). Histones H1 also promote formation of the H3K27me3 mark by the PRC2/EED-EZH2 complex, possibly by facilitating restoration of H3K27me3 post-replication. 1. Kim, JM. et al. (2015) Scientific reports 5, 16714. PMID: 26581166 2. Salinas-Pena, M. et al. (2024) eLife 12. PMID: 38530350 3. Liu, C. et al. (2023) Nature communications 14, 4081. PMID: 37429872 4. Matthews, RE. et al. (2025) Molecular cell 85, 2503-2516.e8. PMID: 40516528 5. Pascal, C. et al. (2023) Molecular cell 83, 3801-3817.e8. PMID: 37922872
Note	For research use only

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Human Histone H1.2 Recombinant Protein (N-GST & C-His).pdf

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