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| カタログ番号 | HW736022 |
|---|---|
| 説明 |
Recombinant Human HSD17B3 Protein, N-His (HW736022) expressed in E. coli, spanning Ser42-Arg310. Purity: >90% by SDS-PAGE.
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | P37058 |
| タンパク質長 | Ser42-Arg310 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 予測分子量 | 32.12 kDa |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | 17-beta-HSD 3, 17-beta-hydroxysteroid dehydrogenase type 3, EC:1.1.1.62, EC:1.1.1.64, EDH17B3, Estradiol 17-beta-dehydrogenase 2, HSD17B3, SDR12C2, Short chain dehydrogenase/reductase family 12C member 2, Testicular 17-beta-hydroxysteroid dehydrogenase, Testosterone 17-beta-dehydrogenase 3 |
| 背景 | 17-beta-hydroxysteroid dehydrogenase type 3 is a ~34 kDa protein. Catalyzes the conversion of 17-oxosteroids to 17beta-hydroxysteroids. Favors the reduction of androstenedione to testosterone. Testosterone is the key androgen driving male development and function. Uses NADPH while the two other EDH17B enzymes use NADH. Androgens such as epiandrosterone, dehydroepiandrosterone, androsterone and androstanedione are accepted as substrates and reduced at C-17. 1. Mindnich, R. et al. (2005) Journal of molecular endocrinology 35, 305-16. PMID: 16216911 2. Engeli, RT. et al. (2016) The Journal of steroid biochemistry and molecular biology 155, 147-54. PMID: 26545797 3. Tsachaki, M. et al. (2017) The Journal of endocrinology 232, 323-335. PMID: 27927697 4. Geissler, WM. et al. (1994) Nature genetics 7, 34-9. PMID: 8075637 |
| 注意事項 | For research use only |
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