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| カタログ番号 | HC775022 |
|---|---|
| 説明 |
Recombinant Human HTR1F Protein, C-His (HC775022) expressed in E. coli, spanning Lys209-Lys290. Purity: >90% by SDS-PAGE.
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | P30939 |
| タンパク質長 | Lys209-Lys290 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 予測分子量 | 37.70 kDa |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | 5-HT-1F, 5-HT1F, 5-hydroxytryptamine receptor 1F, HTR1EL, HTR1F, Serotonin receptor 1F |
| 背景 | 5-hydroxytryptamine receptor 1F is a ~41 kDa protein. G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Receptor for lasmiditan, a drug for the treatment of acute migraine. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. HTR1F is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission by inhibiting adenylate cyclase activity. 1. Klein, MT. et al. (2011) The Journal of pharmacology and experimental therapeutics 337, 860-7. PMID: 21422162 2. Huang, S. et al. (2021) Cell research 31, 1036-1038. PMID: 34239069 3. Adham, N. et al. (1993) Proceedings of the National Academy of Sciences of the United States of America 90, 408-12. PMID: 8380639 4. Lovenberg, TW. et al. (1993) Proceedings of the National Academy of Sciences of the United States of America 90, 2184-8. PMID: 8384716 5. Tan, Y. et al. (2022) Cell discovery 8, 50. PMID: 35610220 |
| 注意事項 | For research use only |
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