Human HTRA2 Recombinant Protein (N-His) (HT447012)

Name: Human HTRA2 Recombinant Protein (N-His)
Brand: abinScience
SKU: HT447012
Price: 211 USD
Availability: InStock

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Numéro de catalogue	HT447012
Description	Recombinant Human HTRA2 Protein, N-His (HT447012) expressed in E. coli, spanning Gln146-Glu458. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Système d'expression	E. coli
Numéro d'accès	O43464
Longueur de protéine	Gln146-Glu458
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Espèces	Homo sapiens (Human)
Nature	Recombinant
Niveau d'endotoxines	Please contact with the lab for this information.
Pureté	>90% as determined by SDS-PAGE.
Masse moléculaire prédite	36.13 kDa
Forme	Lyophilized
Tampon de stockage	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Expédition	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs	EC:3.4.21.108, HTRA2, High temperature requirement protein A2, HtrA2, OMI, Omi stress-regulated endoprotease, PRSS25, Serine protease 25, Serine protease HTRA2, mitochondrial, Serine proteinase OMI
Contexte	Serine protease HTRA2, mitochondrial is a ~48 kDa protein. Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes apoptosis by either relieving the inhibition of BIRC proteins on caspases, leading to an increase in caspase activity; or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves BIRC6 and relieves its inhibition on CASP3, CASP7 and CASP9, but it is also prone to inhibition by BIRC6. Cleaves THAP5 and promotes its degradation during apoptosis. 1. Savopoulos, JW. et al. (2000) Protein expression and purification 19, 227-34. PMID: 10873535 2. Bartke, T. et al. (2004) Molecular cell 14, 801-11. PMID: 15200957 3. Hunkeler, M. et al. (2023) Science (New York, N.Y.) 379, 1105-1111. PMID: 36758104 4. Ehrmann, JF. et al. (2023) Science (New York, N.Y.) 379, 1117-1123. PMID: 36758105 5. Balakrishnan, MP. et al. (2009) American journal of physiology. Heart and circulatory physiology 297, H643-53. PMID: 19502560
Note	For research use only

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Human HTRA2 Recombinant Protein (N-His).pdf

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