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| カタログ番号 | HD731012 |
|---|---|
| 説明 |
Recombinant Human IKZF2 Protein, N-His (HD731012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | Q9UKS7 |
| タンパク質長 | Asp92-Met227 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | HELIOS, IKZF2, Ikaros family zinc finger protein 2, ZNFN1A2, Zinc finger protein Helios |
| 背景 | Zinc finger protein Helios is a ~59 kDa protein. Transcription factor, which stabilizes the noninflammatory phenotype of regulatory T cells (Tregs). May possibly act via STAT5-mediated signaling. Binds IL2 promoter and represses its transcription, possibly by epigenetic silencing, inducing deacetylation of core histones in the IL2 promoter. In Tregs, required for FOXP3 recruitment to the IL2 promoter. Required for outer hair cells maturation and, consequently, for hearing. 1. Mohajeri, A. et al. (2023) Journal of medical genetics 60, 1092-1104. PMID: 37316189 |
| 注意事項 | For research use only |
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