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| カタログ番号 | HD553012 |
|---|---|
| 説明 |
Recombinant Human INPPL1 Protein, N-His (HD553012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | O15357 |
| タンパク質長 | Asp422-Thr730 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | EC:3.1.3.86, INPPL-1, INPPL1, Inositol polyphosphate phosphatase-like protein 1, Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2, Protein 51C, SH2 domain-containing inositol 5'-phosphatase 2, SH2 domain-containing inositol phosphatase 2, SHIP-2, SHIP2 |
| 背景 | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 is a ~138 kDa protein. Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Required for correct mitotic spindle orientation and therefore progression of mitosis. Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear. While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signaling or GLUT4 trafficking. Confers resistance to dietary obesity. 1. Vandeput, F. et al. (2006) Cellular signalling 18, 2193-9. PMID: 16824732 2. Habib, T. et al. (1998) The Journal of biological chemistry 273, 18605-9. PMID: 9660833 3. Dyson, JM. et al. (2001) The Journal of cell biology 155, 1065-79. PMID: 11739414 4. Dyson, JM. et al. (2003) Blood 102, 940-8. PMID: 12676785 5. Prasad, NK. et al. (2005) The Journal of biological chemistry 280, 13129-36. PMID: 15668240 6. Hasegawa, J. et al. (2011) The Journal of cell biology 193, 901-16. PMID: 21624956 7. Prasad, N. et al. (2002) Journal of cell science 115, 3807-15. PMID: 12235291 8. Koch, A. et al. (2005) Oncogene 24, 3436-47. PMID: 15735664 9. Zhuang, G. et al. (2007) The Journal of biological chemistry 282, 2683-94. PMID: 17135240 10. Pengal, RA. et al. (2003) The Journal of biological chemistry 278, 22657-63. PMID: 12690104 |
| 注意事項 | For research use only |
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