

| Numéro de catalogue | HC216012 |
|---|---|
| Description |
Recombinant Human IQGAP1 Protein, N-His (HC216012) expressed in E. coli, spanning Ser962-Ser1345. Purity: >90% by SDS-PAGE.
Highlights
|
| Système d'expression | E. coli |
| Numéro d'accès | P46940 |
| Longueur de protéine | Ser962-Ser1345 |
| Applications | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| Espèces | Homo sapiens (Human) |
| Nature | Recombinant |
| Niveau d'endotoxines | Please contact with the lab for this information. |
| Pureté | >90% as determined by SDS-PAGE. |
| Masse moléculaire prédite | 46.04 kDa |
| Forme | Lyophilized |
| Tampon de stockage | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
| Reconstitution | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Expédition | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Stabilité et stockage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Noms alternatifs | IQGAP1, KIAA0051, Ras GTPase-activating-like protein IQGAP1, p195 |
| Contexte | Ras GTPase-activating-like protein IQGAP1 is a ~189 kDa protein. Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Recruited to the cell cortex by interaction with ILK which allows it to cooperate with its effector DIAPH1 to locally stabilize microtubules and allow stable insertion of caveolae into the plasma membrane. Binds to activated CDC42 but does not stimulate its GTPase activity. Associates with calmodulin. May promote neurite outgrowth. 1. Li, Z. et al. (2005) The Journal of biological chemistry 280, 13871-8. PMID: 15695813 2. Johnson, M. et al. (2011) The international journal of biochemistry & cell biology 43, 65-73. PMID: 20883816 |
| Note | For research use only |
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