Human IRF7 Recombinant Protein (N-His) (HD620012)

Name: Human IRF7 Recombinant Protein (N-His)
Brand: abinScience
SKU: HD620012
Price: 211 USD
Availability: InStock

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Aperçu

Numéro de catalogue	HD620012
Description	Recombinant Human IRF7 Protein, N-His (HD620012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Système d'expression	E. coli
Numéro d'accès	Q92985
Longueur de protéine	Leu289-Ala503
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Espèces	Homo sapiens (Human)
Nature	Recombinant
Niveau d'endotoxines	Please contact with the lab for this information.
Pureté	>90% as determined by SDS-PAGE.
Forme	Lyophilized
Tampon de stockage	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Expédition	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs	IRF-7, IRF7, Interferon regulatory factor 7
Contexte	Interferon regulatory factor 7 is a ~54 kDa protein. Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88-independent pathway and the TLR-activated, MyD88-dependent pathway. Induces transcription of ubiquitin hydrolase USP25 mRNA in response to lipopolysaccharide (LPS) or viral infection in a type I IFN-dependent manner. Required during both the early and late phases of the IFN gene induction but is more critical for the late than for the early phase. 1. Hwang, SW. et al. (2017) Biochemical and biophysical research communications 486, 700-705. PMID: 28342865 2. Kitagawa, Y. et al. (2017) Journal of virology 91. PMID: 28768858 3. Panne, D. et al. (2007) Cell 129, 1111-23. PMID: 17574024 4. Zhang, Q. et al. (2020) Science (New York, N.Y.) 370. PMID: 32972995 5. Marié, I. et al. (2000) Molecular and cellular biology 20, 8803-14. PMID: 11073981 6. Caillaud, A. et al. (2002) The Journal of biological chemistry 277, 49417-21. PMID: 12374802 7. Kawai, T. et al. (2004) Nature immunology 5, 1061-8. PMID: 15361868 8. Sgarbanti, M. et al. (2007) Annals of the New York Academy of Sciences 1095, 325-33. PMID: 17404045
Note	For research use only

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Human IRF7 Recombinant Protein (N-His).pdf

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