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| カタログ番号 | HD995012 |
|---|---|
| 説明 |
Recombinant Human ISG20 Protein, N-His (HD995012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | Q96AZ6 |
| タンパク質長 | Met1-Asp181 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | EC:3.1.13.1, Estrogen-regulated transcript 45 protein, HEM45, ISG20, Interferon-stimulated gene 20 kDa protein, Promyelocytic leukemia nuclear body-associated protein ISG20 |
| 背景 | Interferon-stimulated gene 20 kDa protein is a ~20 kDa protein. Interferon-induced antiviral exoribonuclease that acts mainly on single-stranded RNA. Exhibits antiviral activity against RNA viruses including hepatitis C virus (HCV), hepatitis A virus (HAV) and yellow fever virus (YFV). Inhibition of several viruses such as chikungunya virus (CHIKV) does not involve the degradation of viral RNAs, but rather the inhibition of translation of viral proteins. Exerts a translational control over a large panel of non-self RNA substrates while sparing endogenous transcripts. This activity correlates with the protein's ability to localize in cytoplasmic processing bodies. 1. Nguyen, LH. et al. (2001) Biochemistry 40, 7174-9. PMID: 11401564 2. Espert, L. et al. (2003) The Journal of biological chemistry 278, 16151-8. PMID: 12594219 3. Espert, L. et al. (2005) The Journal of general virology 86, 2221-2229. PMID: 16033969 4. Espert, L. et al. (2006) Journal of cellular biochemistry 98, 1320-33. PMID: 16514659 5. Zhou, Z. et al. (2011) Virology 409, 175-88. PMID: 21036379 6. Wu, N. et al. (2019) PLoS pathogens 15, e1008093. PMID: 31600344 |
| 注意事項 | For research use only |
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