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| カタログ番号 | HD245012 |
|---|---|
| 説明 |
Recombinant Human JMJD1C Protein, N-His (HD245012) expressed in E. coli, spanning Glu2141-Glu2502. Purity: >90% by SDS-PAGE.
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | Q15652 |
| タンパク質長 | Glu2141-Glu2502 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 予測分子量 | 43.62 kDa |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | EC:1.14.11.-, JHDM2C, JMJD1C, Jumonji domain-containing protein 1C, KIAA1380, Probable JmjC domain-containing histone demethylation protein 2C, TR-interacting protein 8, TRIP-8, TRIP8, Thyroid receptor-interacting protein 8 |
| 背景 | Jumonji domain-containing protein 1C is a ~284 kDa protein. Demethylates lysine in proteins, such as STAT3 or MDC1. Demethylates MDC1, thereby promoting MDC1-RNF8 interaction and facilitating RNF8-dependent MDC1 ubiquitination essential for double-strand break (DSB) repair. Demethylation of STAT3 at 'Lys-140' facilitates its interactions with the phosphatase PTPN6 and restrains STAT3 activation. It is uncertain whether JMJD1C removes methyl groups from histone proteins as the other JMJD1/KDM3 proteins do. Nevertheless, JMJD1C may act as a context-specific histone demethylase. 1. Watanabe, S. et al. (2013) Nature structural & molecular biology 20, 1425-33. PMID: 24240613 2. Brauchle, M. et al. (2013) PloS one 8, e60549. PMID: 23593242 3. Viscarra, JA. et al. (2020) Nature communications 11, 796. PMID: 32034158 |
| 注意事項 | For research use only |
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