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| カタログ番号 | HC265012 |
|---|---|
| 説明 |
Recombinant Human KCNAB1 Protein, N-His (HC265012) expressed in E. coli, spanning Met89-Ser419. Purity: >90% by SDS-PAGE.
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | Q14722 |
| タンパク質長 | Met89-Ser419 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 予測分子量 | 39.23 kDa |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | EC:1.1.1.-, K(+) channel subunit beta-1, KCNA1B, KCNAB1, Kv-beta-1, Voltage-gated potassium channel subunit beta-1 |
| 背景 | Voltage-gated potassium channel subunit beta-1 is a ~46 kDa protein. Regulatory subunit of the voltage-gated potassium (Kv) Shaker channels composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunits. The beta-1/KCNAB1 cytoplasmic subunit mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N-terminal domain and increases the speed of channel closure for other family members. Promotes the inactivation of Kv1.1/KCNA1, Kv1.2/KCNA2, Kv1.4/KCNA4, Kv1.5/KCNA5 and Kv1.6/KCNA6 alpha subunit-containing channels. Displays nicotinamide adenine dinucleotide phosphate (NADPH)-dependent aldoketoreductase activity by catalyzing the NADPH-dependent reduction of a variety of endogenous aldehydes and ketones. The binding of NADPH is required for efficient down-regulation of potassium channel activity. 1. Imbrici, P. et al. (2006) The European journal of neuroscience 24, 3073-83. PMID: 17156368 2. Tipparaju, SM. et al. (2007) Biochemical and biophysical research communications 359, 269-76. PMID: 17540341 3. Peters, CJ. et al. (2009) Channels (Austin, Tex.) 3, 314-22. PMID: 19713757 4. England, SK. et al. (1995) The Journal of biological chemistry 270, 28531-4. PMID: 7499366 5. England, SK. et al. (1995) Proceedings of the National Academy of Sciences of the United States of America 92, 6309-13. PMID: 7603988 6. Accili, EA. et al. (1998) The Journal of physiology 512 ( Pt 2), 325-36. PMID: 9763623 7. Maylie, B. et al. (2002) The Journal of neuroscience : the official journal of the Society for Neuroscience 22, 4786-93. PMID: 12077175 8. Williams, CP. et al. (2002) The Journal of pharmacology and experimental therapeutics 302, 545-50. PMID: 12130714 9. Bhalla, T. et al. (2004) Nature structural & molecular biology 11, 950-6. PMID: 15361858 10. McCormack, K. et al. (1995) FEBS letters 370, 32-6. PMID: 7649300 |
| 注意事項 | For research use only |
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