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| カタログ番号 | HX945012 |
|---|---|
| 説明 |
Recombinant Human KCNJ2/Kir2.1 Protein, N-His (HX945012) expressed in E. coli, spanning Lys185-Glu349. Purity: >90% by SDS-PAGE.
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | P63252 |
| タンパク質長 | Lys185-Glu349 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 予測分子量 | 21.48 kDa |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | Cardiac inward rectifier potassium channel, IRK-1, IRK1, Inward rectifier K(+) channel Kir2.1, Inward rectifier potassium channel 2, KCNJ2, Potassium channel, inwardly rectifying subfamily J member 2, hIRK1 |
| 背景 | Inward rectifier potassium channel 2 is a ~48 kDa protein. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium or cesium. Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. 1. Fernandes, CAH. et al. (2022) Science advances 8, eabq8489. PMID: 36149965 2. Wood, LS. et al. (1995) Gene 163, 313-7. PMID: 7590287 3. Tare, M. et al. (1998) The Journal of physiology 506 ( Pt 2), 303-18. PMID: 9490857 4. Raab-Graham, KF. et al. (1994) Neuroreport 5, 2501-5. PMID: 7696590 |
| 注意事項 | For research use only |
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