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| カタログ番号 | HD176012 |
|---|---|
| 説明 |
Recombinant Human KCNMA1 Protein, N-His (HD176012) expressed in E. coli, spanning Lys408-Arg716. Purity: >90% by SDS-PAGE.
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | Q12791 |
| タンパク質長 | Lys408-Arg716 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 予測分子量 | 37.82 kDa |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | BK channel, BKCA alpha, Calcium-activated potassium channel subunit alpha-1, Calcium-activated potassium channel, subfamily M subunit alpha-1, K(VCA)alpha, KCNMA, KCNMA1, KCa1.1, Maxi K channel, MaxiK, SLO, Slo homolog, Slo-alpha, Slo1, Slowpoke homolog, hSlo |
| 背景 | Calcium-activated potassium channel subunit alpha-1 is a ~137 kDa protein. Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. 1. Tang, XD. et al. (2003) Nature 425, 531-5. PMID: 14523450 2. Li, X. et al. (2018) European journal of human genetics : EJHG 26, 220-229. PMID: 29330545 3. Liang, L. et al. (2019) Human molecular genetics 28, 2937-2951. PMID: 31152168 4. Niu, L. et al. (2020) Proceedings of the National Academy of Sciences of the United States of America 117, 25128-25137. PMID: 32958651 |
| 注意事項 | For research use only |
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